[HTML][HTML] Recent advances in mass spectrometry based clinical proteomics: applications to cancer research

A Macklin, S Khan, T Kislinger - Clinical proteomics, 2020 - Springer
… focus on the discovery of clinically-relevant biomarkers, there … and PgR are used to classify
breast cancer subtypes which has … sample preparation in clinical studies have been shown in …

Clinical potential of mass spectrometry-based proteogenomics

B Zhang, JR Whiteaker, AN Hoofnagle… - Nature Reviews …, 2019 - nature.com
… of cancer biology and biomarker and drug target discovery in … from two PDX models of breast
cancer demonstrate that only … and proteogenomic biomarker discovery to clinical validation, …

[HTML][HTML] Identification of novel alternative splicing biomarkers for breast cancer with LC/MS/MS and RNA-Seq

F Zhang, CK Deng, M Wang, B Deng, R Barber… - BMC …, 2020 - Springer
… to discover novel alternative splicing biomarkers from the … and 90% of them were confirmed
as the predicted AS events by … and 40 breast cancer plasma samples, we demonstrated that …

[HTML][HTML] Mass spectrometry-based chemical mapping and profiling toward molecular understanding of diseases in precision medicine

Y Hu, Z Wang, L Liu, J Zhu, D Zhang, M Xu… - Chemical …, 2021 - pubs.rsc.org
… Another study demonstrated that quantitative biomarker … supposedly homogeneous group
of breast cancer patients, allowing for … It was confirmed that the classification of breast cancer

[HTML][HTML] An integrated quantitative proteomics workflow for cancer biomarker discovery and validation in plasma

V Kumar, S Ray, S Ghantasala, S Srivastava - Frontiers in oncology, 2020 - frontiersin.org
… in various cancers, while we have demonstrated here a … in instrumentation and mass
spectrometry-based platforms have … of plasma from patients with breast cancer: stage-specific …

[HTML][HTML] Data-independent acquisition mass spectrometry (DIA-MS) for proteomic applications in oncology

L Krasny, PH Huang - Molecular omics, 2021 - pubs.rsc.org
… acquisition as a rapid proteomic pipeline for the analysis of … 1078 breast cancer patients
respectively, which confirmed the … DIA-MS has shown some success in biomarker discovery is in …

Mass spectrometry-based draft of the mouse proteome

P Giansanti, P Samaras, Y Bian, C Meng, A Coluccio… - Nature …, 2022 - nature.com
… Our analysis confirmed expression of 13,538 genes with previous … We and others have
previously shown that the proteomic … of interesting molecular pharmacodynamics biomarkers. For …

Internal standard triggered-parallel reaction monitoring mass spectrometry enables multiplexed quantification of candidate biomarkers in plasma

JJ Kennedy, JR Whiteaker, RG Ivey, A Burian… - Analytical …, 2022 - ACS Publications
… Previously, mass spectrometry-based approaches have been … list of 1314 candidate breast
cancer biomarkers. Since these … We demonstrate that IS-PRM can be deployed on plasma …

[HTML][HTML] Mass spectrometry-based proteomics as an emerging tool in clinical laboratories

AG Birhanu - Clinical Proteomics, 2023 - Springer
… emphasis on biomarker discovery and validation to help with … to neoadjuvant chemotherapy
in breast cancer patients [24]. … MS-based protein biomarkers are shown in Table 1 below. …

[HTML][HTML] Mass spectrometry based proteomics and metabolomics in personalized oncology

T Kowalczyk, M Ciborowski, J Kisluk… - … et Biophysica Acta (BBA …, 2020 - Elsevier
… Such studies, focused on cancer biomarkers discovery or … biomarkers of breast cancer
metastasis. By the use of iTRAQ-based quantitative tissue proteomics, the authors have shown